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KMID : 0363219950330061124
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Korean Journal of Dermatology
1995 Volume.33 No. 6 p.1124 ~ p.1128
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A Case of PyodermaGangrenosum Treated with Cyclosporine
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Abstract
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We present herein a case of pyoderma gangrenosum, which showed good response to cyclosporine therapy. The patient, a 47-year-old man, had suffered from a skin defect on the left anterior chest 2 months before the rapidly spreading pustules and
ulcer
with an inflammed, irregular undermined border appeared together with a hemorrhagic base which developed on his left anterior chest and upper abdomen.
Cyclosporine was given orally in a dose of 150mg three times daily for 2 weeks, and tapering to 100mg three times daily for the next 3 weeks. Clinical imporovement was observed after 14 day's treatment and all the skin lesions were the 5-week
period of
treatment, blood urea nitrogen and creatinine rose to 29 and 1.8 mg/dl. Cyclosporine was stopped and then the patient was given prednisolone (10mg/day) in addition to dapsone(50mg/day) for 1 month. Recurrence has not been observed.
(Kor J Dermatol 1995;33(6) : 1124~1128)
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